Phosphate Interacts With PTHrP to Regulate Endochondral Bone Formation
نویسندگان
چکیده
منابع مشابه
PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development.
Endochondral bone development is a fascinating story of proliferation, maturation, and death. An understanding of this process at the molecular level is emerging. In particular, significant advances have been made in understanding the role of parathyroid-hormone-related peptide (PTHrP), parathyroid hormone (PTH), and the PTH/PTHrP receptor in endochondral bone development. Mutations of the PTH/...
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Previously, we showed that expression of a dominant-negative form of the transforming growth factor beta (TGF-beta) type II receptor in skeletal tissue resulted in increased hypertrophic differentiation in growth plate and articular chondrocytes, suggesting a role for TGF-beta in limiting terminal differentiation in vivo. Parathyroid hormone-related peptide (PTHrP) has also been demonstrated to...
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متن کاملRole of PTHrP and PTH-1 receptor in endochondral bone development.
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in en...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2014
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2014-1315